The Optimum Use of Acid Preservatives in Oil-Water Systems: Benzoic Acid in Peanut Oil-Water

The Optimum Use of Acid Preservatives in Oil-Water Systems: Benzoic Acid in Peanut Oil-Water

It is shown that the frequent practice of stating mg./cc. of an acid preservative in an oil-water system has no bacteriostatic meaning unless the dissociation constant of the acid, the intrinsic distribution constant of the undissociated acid in both phases, the pH of the preparation, the relative v...

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Veröffentlicht in:Journal of the American Pharmaceutical Association (Scientific ed.) 1953-12, Vol.42 (12), p.736-739
Hauptverfasser: Garrett, Edward R., Woods, Oliver R.
Format: Artikel
Sprache:eng
Schlagworte:
Benzoates
Benzoic Acid
Peanut Oil
Plant Oils
Preservatives, Pharmaceutical
Water
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Zusammenfassung:It is shown that the frequent practice of stating mg./cc. of an acid preservative in an oil-water system has no bacteriostatic meaning unless the dissociation constant of the acid, the intrinsic distribution constant of the undissociated acid in both phases, the pH of the preparation, the relative volumes of the phases, and the minimum concentration of the undissociated acid in the aqueous phase necessary for preservative action are specified. The necessary constants are evaluated for benzoic acid in a peanut oil-water system and conditions for optimum use of this preservative are given.
ISSN:0095-9553
1930-2304
DOI:10.1002/jps.3030421210