Chronic Oral Toxicity Studies of Triacetyl Diphenyl Isatin in Dogs and Rats

The results of acute and chronic toxicity studies of Triacetyl diphenyl isatin (TDI) on rats and on dogs are reorted. The data obtained indicate TDI is only slightly toxic and cannot be classizd as a high-grade irritant. In preliminary tests, human adult subjects showed increasing laxative effects with increasing doses. Relatively few undesirable side effects were reported, and those were moderate or slight in degree.