Local Anesthetics. I. Phenylurethanes of Dialkylamino Alcohols

Local Anesthetics. I. Phenylurethanes of Dialkylamino Alcohols

Phenylurethanes of series of 2-dialkylaminoethanols, 1-dialkylamino-2-propanols and 3-dialkylaminopropanols produce local anesthesia which increases in duration with the molecular weight of the amino alkyl groups, the most active of the compounds tested, in each series, being the dibutyl derivative....

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Veröffentlicht in:Journal of the American Pharmaceutical Association (Scientific ed.) 1951-04, Vol.40 (4), p.202-204
Hauptverfasser: Bandelin, F.J., Tuschhoff, J.V.
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Sprache:eng
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container_end_page 204
container_issue 4
container_start_page 202
container_title Journal of the American Pharmaceutical Association (Scientific ed.)
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creator Bandelin, F.J.
Tuschhoff, J.V.
description Phenylurethanes of series of 2-dialkylaminoethanols, 1-dialkylamino-2-propanols and 3-dialkylaminopropanols produce local anesthesia which increases in duration with the molecular weight of the amino alkyl groups, the most active of the compounds tested, in each series, being the dibutyl derivative. Higher homologs are too insoluble to be evaluated by the methods described. Test results obtained with cocaine and procaine are included for comparison.
doi_str_mv 10.1002/jps.3030400410
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Phenylurethanes of Dialkylamino Alcohols</atitle><jtitle>Journal of the American Pharmaceutical Association (Scientific ed.)</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1951-04</date><risdate>1951</risdate><volume>40</volume><issue>4</issue><spage>202</spage><epage>204</epage><pages>202-204</pages><issn>0095-9553</issn><eissn>1930-2304</eissn><abstract>Phenylurethanes of series of 2-dialkylaminoethanols, 1-dialkylamino-2-propanols and 3-dialkylaminopropanols produce local anesthesia which increases in duration with the molecular weight of the amino alkyl groups, the most active of the compounds tested, in each series, being the dibutyl derivative. Higher homologs are too insoluble to be evaluated by the methods described. Test results obtained with cocaine and procaine are included for comparison.</abstract><cop>Washington, D. C</cop><pub>Elsevier Inc</pub><doi>10.1002/jps.3030400410</doi><tpages>3</tpages></addata></record>
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title Local Anesthetics. I. Phenylurethanes of Dialkylamino Alcohols
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