Local Anesthetics. I. Phenylurethanes of Dialkylamino Alcohols

Phenylurethanes of series of 2-dialkylaminoethanols, 1-dialkylamino-2-propanols and 3-dialkylaminopropanols produce local anesthesia which increases in duration with the molecular weight of the amino alkyl groups, the most active of the compounds tested, in each series, being the dibutyl derivative. Higher homologs are too insoluble to be evaluated by the methods described. Test results obtained with cocaine and procaine are included for comparison.