Pharmacokinetic Profile of Flosequinan in Patients with Compromised Renal Function

The pharmacokinetics of flosequinan and its major active metabolite (BTS 53 554, 7-fluoro-1-methyl-3 methylsulfinyl-4-quinolone, 1) were investigated following a single oral dose of 100mg of flosequinan in 20 patients with severe renal dysfunction (creatinine clearance,

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1993-03, Vol.82 (3), p.282-285
Hauptverfasser:	Gallo, Bruno V., Hinson, James L., Weidler, Donald J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Antihypertensive agents Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Creatinine - urine Fatigue - metabolism Female Humans Kidney - metabolism Kidney - physiology Kidney Diseases - metabolism Male Medical sciences Middle Aged Oliguria - metabolism Pharmacology. Drug treatments Quinolines - administration & dosage Quinolines - adverse effects Quinolines - pharmacokinetics
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Beschreibung
Zusammenfassung:	The pharmacokinetics of flosequinan and its major active metabolite (BTS 53 554, 7-fluoro-1-methyl-3 methylsulfinyl-4-quinolone, 1) were investigated following a single oral dose of 100mg of flosequinan in 20 patients with severe renal dysfunction (creatinine clearance,
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600820313