Preparation and Antidiabetic Activity of New Substituted 3,5-Diarylpyrazolesulfonylurea Derivatives II: Structure-Activity Relationship

Four series of substituted p-(3,5-diaryl-2-pyrazoline-1) benzenesulfonylurea and thiourea derivatives, along with their corresponding substituted p-(3,5-diarylpyrazole-1) benzenesulfonylurea and thiourea derivatives, were prepared for evaluation as hypoglycemic agents. Preliminary biological testing...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1987-08, Vol.76 (8), p.626-632
Hauptverfasser:	Soliman, Raafat, Faid-Allah, Hassan M., El Sadany, Samir K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan Animals Biological and medical sciences Diabetes Mellitus, Experimental - drug therapy Female General pharmacology Hypoglycemic Agents - pharmacology Magnetic Resonance Spectroscopy Medical sciences Mice Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Structure-Activity Relationship Sulfonylurea Compounds - pharmacology
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container_end_page	632
container_issue	8
container_start_page	626
container_title	Journal of pharmaceutical sciences
container_volume	76
creator	Soliman, Raafat Faid-Allah, Hassan M. El Sadany, Samir K.
description	Four series of substituted p-(3,5-diaryl-2-pyrazoline-1) benzenesulfonylurea and thiourea derivatives, along with their corresponding substituted p-(3,5-diarylpyrazole-1) benzenesulfonylurea and thiourea derivatives, were prepared for evaluation as hypoglycemic agents. Preliminary biological testing revealed that the new compounds possess potent hypoglycemic activity.
doi_str_mv	10.1002/jps.2600760808
format	Article
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Pharm. Sci</addtitle><description>Four series of substituted p-(3,5-diaryl-2-pyrazoline-1) benzenesulfonylurea and thiourea derivatives, along with their corresponding substituted p-(3,5-diarylpyrazole-1) benzenesulfonylurea and thiourea derivatives, were prepared for evaluation as hypoglycemic agents. Preliminary biological testing revealed that the new compounds possess potent hypoglycemic activity.</description><subject>Alloxan</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemical properties. 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Drug treatments</topic><topic>Physicochemical properties. Structure-activity relationships</topic><topic>Structure-Activity Relationship</topic><topic>Sulfonylurea Compounds - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soliman, Raafat</creatorcontrib><creatorcontrib>Faid-Allah, Hassan M.</creatorcontrib><creatorcontrib>El Sadany, Samir K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soliman, Raafat</au><au>Faid-Allah, Hassan M.</au><au>El Sadany, Samir K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and Antidiabetic Activity of New Substituted 3,5-Diarylpyrazolesulfonylurea Derivatives II: Structure-Activity Relationship</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. 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source	MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection
subjects	Alloxan Animals Biological and medical sciences Diabetes Mellitus, Experimental - drug therapy Female General pharmacology Hypoglycemic Agents - pharmacology Magnetic Resonance Spectroscopy Medical sciences Mice Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Structure-Activity Relationship Sulfonylurea Compounds - pharmacology
title	Preparation and Antidiabetic Activity of New Substituted 3,5-Diarylpyrazolesulfonylurea Derivatives II: Structure-Activity Relationship
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