Preparation and Antidiabetic Activity of New Substituted 3,5-Diarylpyrazolesulfonylurea Derivatives II: Structure-Activity Relationship

Four series of substituted p-(3,5-diaryl-2-pyrazoline-1) benzenesulfonylurea and thiourea derivatives, along with their corresponding substituted p-(3,5-diarylpyrazole-1) benzenesulfonylurea and thiourea derivatives, were prepared for evaluation as hypoglycemic agents. Preliminary biological testing...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1987-08, Vol.76 (8), p.626-632
Hauptverfasser:	Soliman, Raafat, Faid-Allah, Hassan M., El Sadany, Samir K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan Animals Biological and medical sciences Diabetes Mellitus, Experimental - drug therapy Female General pharmacology Hypoglycemic Agents - pharmacology Magnetic Resonance Spectroscopy Medical sciences Mice Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Structure-Activity Relationship Sulfonylurea Compounds - pharmacology
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Zusammenfassung:	Four series of substituted p-(3,5-diaryl-2-pyrazoline-1) benzenesulfonylurea and thiourea derivatives, along with their corresponding substituted p-(3,5-diarylpyrazole-1) benzenesulfonylurea and thiourea derivatives, were prepared for evaluation as hypoglycemic agents. Preliminary biological testing revealed that the new compounds possess potent hypoglycemic activity.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600760808