In Vitro Stability of Sodium NitroprussideSolutions for Intravenous Administration

A sensitive high-performance liquid chromatographic assay for nitroprusside using an ion-exchange column and UV detection was developed to evaluate the stability of aqueous solutions of sodium nitroprusside in light-protected glass and plastic containers and during simulated infusions. The results s...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1984-06, Vol.73 (6), p.838-839
Hauptverfasser:	Mahony, Cheryl, Brown, James E., Stargel, W. Wayne, Verghese, Chacko P., Bjornsson, Thorir D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Sodium nitroprusside—in vitro stability, solutions, intravenous administration, HPLC Stability—in vitro, sodium nitroprusside solutions, intravenous administration, HPLC
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A sensitive high-performance liquid chromatographic assay for nitroprusside using an ion-exchange column and UV detection was developed to evaluate the stability of aqueous solutions of sodium nitroprusside in light-protected glass and plastic containers and during simulated infusions. The results showed that sodium nitroprusside is stable in 5% dextrose, normal saline, and lactated Ringer's solutions in light-protected glass or plastic containers. In addition, there was no decrease in the delivered potency of sodium nitroprusside solutions during simulated infusions lasting up to 24h.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600730636