Potential Alkylating Agents Derived from Benzimidazole and Benzothiazole

Several benzimidazole and benzothiazole alkylating agents, bearing structural modification of certain drugs, were synthesized and evaluated for anticancer activity. Among the products, the dihydro-chloride salt of 2-{p-[2-(bis(2-chloroethyl)amino)ethoxy]phenyl}benzimidazole (VI) exhibited a high ant...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1982-09, Vol.71 (9), p.991-993
Hauptverfasser:	Omar, A.-mohsen M.E., Habib, N.S., Aboulwafa, Omaima M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - chemical synthesis Alkylating agents-derived from benzimidazole and benzothiazole Alkylating agents—derived from benzimidazole and benzothiazole, potential Animals Antineoplastic Agents - chemical synthesis benzimidazole Benzimidazole-potential alkylating agents Benzimidazoles - chemical synthesis Benzimidazoles - pharmacology Benzimidazole—potential alkylating agents, benzothiazole benzothiazole Benzothiazole-potential alkylating agents Benzothiazole—potential alkylating agents, benzimidazole Chemical Phenomena Chemistry Leukemia P388 - drug therapy Mice potential Thiazoles - chemical synthesis Thiazoles - pharmacology
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Zusammenfassung:	Several benzimidazole and benzothiazole alkylating agents, bearing structural modification of certain drugs, were synthesized and evaluated for anticancer activity. Among the products, the dihydro-chloride salt of 2-{p-[2-(bis(2-chloroethyl)amino)ethoxy]phenyl}benzimidazole (VI) exhibited a high antileukemic activity in P-388 lymphocytic leukemia.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600710909