Possible Ion-Pair-Mediated Absorption of Mixidine II: Plasma Levels and Histology

Plasma intact 14C-mixidine levels in rats increased when the drug was administered intraduodenally with 1:3 and 1:5 molar ratios of 2-naphthalenesulfonic acid. Upon histological examination of the duodenums, similar doses of mixidine combined with Z-naphthalenesulfonic acid produced no dose-related...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1978-07, Vol.67 (7), p.948-950
Hauptverfasser:	Douglas Walkling, W., Holmes, Donald G., Cressman, William A., Dix, Robert K., Piperno, Elliot, Harris Mosher, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption Absorption-mixidine Absorption-mixidine, effect of intraduodenal administration with various ratios of 2-naphthalenesulfonic acid as counterion Animals coronary-mixidine Dose-Response Relationship, Drug Duodenum - drug effects effect of intraduodenal administration with various ratios of 2-naphthalenesulfonic acid as counterion Hydrogen-Ion Concentration Intestinal Absorption - drug effects intraduodenal administration with various ratios of 2-naphthalenesulfonic acid as counterion Ion-pair formation-effect on mixidine absorption Ion-pair formation-effect on mixidine absorption, intraduodenal administration with various ratios of 2-naphthalenesulfonic acid as counterion Male Mixidine-absorption Mixidine-absorption, effect of intraduodenal administration with various ratios of 2-naphthalenesulfonic acid as counterion Naphthalenesulfonates - pharmacology Pyrrolidines - metabolism Pyrrolidines - toxicity Rats Vasodilators Vasodilators, coronary-mixidine, absorption, effect of intraduodenal administration with various ratios of 2-naphthalenesulfonic acid as counterion
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Zusammenfassung:	Plasma intact 14C-mixidine levels in rats increased when the drug was administered intraduodenally with 1:3 and 1:5 molar ratios of 2-naphthalenesulfonic acid. Upon histological examination of the duodenums, similar doses of mixidine combined with Z-naphthalenesulfonic acid produced no dose-related lesions. These and previous observations demonstrate that mixidine absorption may be enhanced by ion-pair formation.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600670719