Analysis of the Prodrug 7-Acetylacroninium Perchlorate in Presence of the Parent Compound Acronine
Analysis of acronine and the prodrug acetylacroninium perchlorate in parenteral solutions is described. The unstable prodrug reacts quantitatively with the nucleophilic agent aniline by an unusual mechanism to form a phenylimino derivative of acronine. This derivative and acronine itself were determ...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1978-02, Vol.67 (2), p.237-239 |
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| container_end_page | 239 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Hansen, Anne Bagger Kreilgård, Bo Huang, Chong-Heng Repta, A.J. |
| description | Analysis of acronine and the prodrug acetylacroninium perchlorate in parenteral solutions is described. The unstable prodrug reacts quantitatively with the nucleophilic agent aniline by an unusual mechanism to form a phenylimino derivative of acronine. This derivative and acronine itself were determined by a spectrophotometric two-component method. |
| doi_str_mv | 10.1002/jps.2600670228 |
| format | Article |
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The unstable prodrug reacts quantitatively with the nucleophilic agent aniline by an unusual mechanism to form a phenylimino derivative of acronine. This derivative and acronine itself were determined by a spectrophotometric two-component method.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600670228</identifier><identifier>PMID: 621645</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>7-Acetylacroninium perchlorate-two-component spectrophotometric analysis with acronine in parenteral solutions ; Acronine - analogs & derivatives ; Acronine - analysis ; Acronine - chemical synthesis ; acronine and 7-acetylacroninium perchlorate in parenteral solutions ; Acronine-two-component spectrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions ; Alkaloids - analysis ; Antineoplastic agents-acronine ; Antineoplastic agents—acronine, two-component spestrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions ; Antineoplastic agents—acronine, two‐component spectrophotometric analysis with 7‐acetylacroninium perchlorate in parenteral solutions ; Chromatography, Thin Layer ; Drug Interactions ; Light ; Prodrugs-7-acetylacroninium perchlorate ; Prodrugs—7-acetylacroninium perchlorate, two-component spectrophotometric analysis with acronine in parenteral solutions ; Spectrophotometry ; Spectrophotometry-two-component analysis ; Spectrophotometry—two-component analysis, acronine and 7-acetylacroninium perchlorate in parenteral solutions ; two-component spectrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions ; two-component spectrophotometric analysis with acronine in parenteral solutions</subject><ispartof>Journal of pharmaceutical sciences, 1978-02, Vol.67 (2), p.237-239</ispartof><rights>1978 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4268-507856e0bba909029b33f99accf2a5518110ef24ae0c047c45391c5265e0dad73</citedby><cites>FETCH-LOGICAL-c4268-507856e0bba909029b33f99accf2a5518110ef24ae0c047c45391c5265e0dad73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600670228$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600670228$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/621645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hansen, Anne Bagger</creatorcontrib><creatorcontrib>Kreilgård, Bo</creatorcontrib><creatorcontrib>Huang, Chong-Heng</creatorcontrib><creatorcontrib>Repta, A.J.</creatorcontrib><title>Analysis of the Prodrug 7-Acetylacroninium Perchlorate in Presence of the Parent Compound Acronine</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Analysis of acronine and the prodrug acetylacroninium perchlorate in parenteral solutions is described. The unstable prodrug reacts quantitatively with the nucleophilic agent aniline by an unusual mechanism to form a phenylimino derivative of acronine. This derivative and acronine itself were determined by a spectrophotometric two-component method.</description><subject>7-Acetylacroninium perchlorate-two-component spectrophotometric analysis with acronine in parenteral solutions</subject><subject>Acronine - analogs & derivatives</subject><subject>Acronine - analysis</subject><subject>Acronine - chemical synthesis</subject><subject>acronine and 7-acetylacroninium perchlorate in parenteral solutions</subject><subject>Acronine-two-component spectrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions</subject><subject>Alkaloids - analysis</subject><subject>Antineoplastic agents-acronine</subject><subject>Antineoplastic agents—acronine, two-component spestrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions</subject><subject>Antineoplastic agents—acronine, two‐component spectrophotometric analysis with 7‐acetylacroninium perchlorate in parenteral solutions</subject><subject>Chromatography, Thin Layer</subject><subject>Drug Interactions</subject><subject>Light</subject><subject>Prodrugs-7-acetylacroninium perchlorate</subject><subject>Prodrugs—7-acetylacroninium perchlorate, two-component spectrophotometric analysis with acronine in parenteral solutions</subject><subject>Spectrophotometry</subject><subject>Spectrophotometry-two-component analysis</subject><subject>Spectrophotometry—two-component analysis, acronine and 7-acetylacroninium perchlorate in parenteral solutions</subject><subject>two-component spectrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions</subject><subject>two-component spectrophotometric analysis with acronine in parenteral solutions</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQQC3EVymsTAz5AylnJ7aTsar4VIFKgBgtx7mAIU0qOwX673EVVMSAmDzce3fyI-SYwogCsNPXhR8xASAkMJZtkQHlDGIBVG6TQQBYnPA03ycH3r9CwIDzPbIrGBUpH5Bi3Oh65a2P2irqXjCaubZ0y-dIxmOD3arWxrWNbexyHs3QmZe6dbrDyDaBRI-NwY2pHTZdNGnni3bZlNG4N_GQ7FS69nj0_Q7J4_nZw-Qynt5dXE3G09ikTGQxB5lxgVAUOoccWF4kSZXn2piKac5pRilgxVKNYCCVJuVJTg1ngiOUupTJkIz6veGu9w4rtXB2rt1KUVDrVCqkUj-pgnDSC4tlMcdyg_dtwjjvxx-2xtU_y9T17P7X6rh3re_wc-Nq96aETCRXT7cXKpNZOn1IbtRT4LOexxDo3aJT3th13NI6NJ0qW_vXL74ADmuW8Q</recordid><startdate>197802</startdate><enddate>197802</enddate><creator>Hansen, Anne Bagger</creator><creator>Kreilgård, Bo</creator><creator>Huang, Chong-Heng</creator><creator>Repta, A.J.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197802</creationdate><title>Analysis of the Prodrug 7-Acetylacroninium Perchlorate in Presence of the Parent Compound Acronine</title><author>Hansen, Anne Bagger ; Kreilgård, Bo ; Huang, Chong-Heng ; Repta, A.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4268-507856e0bba909029b33f99accf2a5518110ef24ae0c047c45391c5265e0dad73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>7-Acetylacroninium perchlorate-two-component spectrophotometric analysis with acronine in parenteral solutions</topic><topic>Acronine - analogs & derivatives</topic><topic>Acronine - analysis</topic><topic>Acronine - chemical synthesis</topic><topic>acronine and 7-acetylacroninium perchlorate in parenteral solutions</topic><topic>Acronine-two-component spectrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions</topic><topic>Alkaloids - analysis</topic><topic>Antineoplastic agents-acronine</topic><topic>Antineoplastic agents—acronine, two-component spestrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions</topic><topic>Antineoplastic agents—acronine, two‐component spectrophotometric analysis with 7‐acetylacroninium perchlorate in parenteral solutions</topic><topic>Chromatography, Thin Layer</topic><topic>Drug Interactions</topic><topic>Light</topic><topic>Prodrugs-7-acetylacroninium perchlorate</topic><topic>Prodrugs—7-acetylacroninium perchlorate, two-component spectrophotometric analysis with acronine in parenteral solutions</topic><topic>Spectrophotometry</topic><topic>Spectrophotometry-two-component analysis</topic><topic>Spectrophotometry—two-component analysis, acronine and 7-acetylacroninium perchlorate in parenteral solutions</topic><topic>two-component spectrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions</topic><topic>two-component spectrophotometric analysis with acronine in parenteral solutions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hansen, Anne Bagger</creatorcontrib><creatorcontrib>Kreilgård, Bo</creatorcontrib><creatorcontrib>Huang, Chong-Heng</creatorcontrib><creatorcontrib>Repta, A.J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hansen, Anne Bagger</au><au>Kreilgård, Bo</au><au>Huang, Chong-Heng</au><au>Repta, A.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the Prodrug 7-Acetylacroninium Perchlorate in Presence of the Parent Compound Acronine</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1978-02</date><risdate>1978</risdate><volume>67</volume><issue>2</issue><spage>237</spage><epage>239</epage><pages>237-239</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Analysis of acronine and the prodrug acetylacroninium perchlorate in parenteral solutions is described. The unstable prodrug reacts quantitatively with the nucleophilic agent aniline by an unusual mechanism to form a phenylimino derivative of acronine. This derivative and acronine itself were determined by a spectrophotometric two-component method.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>621645</pmid><doi>10.1002/jps.2600670228</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1978-02, Vol.67 (2), p.237-239 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jps_2600670228 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | 7-Acetylacroninium perchlorate-two-component spectrophotometric analysis with acronine in parenteral solutions Acronine - analogs & derivatives Acronine - analysis Acronine - chemical synthesis acronine and 7-acetylacroninium perchlorate in parenteral solutions Acronine-two-component spectrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions Alkaloids - analysis Antineoplastic agents-acronine Antineoplastic agents—acronine, two-component spestrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions Antineoplastic agents—acronine, two‐component spectrophotometric analysis with 7‐acetylacroninium perchlorate in parenteral solutions Chromatography, Thin Layer Drug Interactions Light Prodrugs-7-acetylacroninium perchlorate Prodrugs—7-acetylacroninium perchlorate, two-component spectrophotometric analysis with acronine in parenteral solutions Spectrophotometry Spectrophotometry-two-component analysis Spectrophotometry—two-component analysis, acronine and 7-acetylacroninium perchlorate in parenteral solutions two-component spectrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions two-component spectrophotometric analysis with acronine in parenteral solutions |
| title | Analysis of the Prodrug 7-Acetylacroninium Perchlorate in Presence of the Parent Compound Acronine |
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