Analysis of the Prodrug 7-Acetylacroninium Perchlorate in Presence of the Parent Compound Acronine

Analysis of acronine and the prodrug acetylacroninium perchlorate in parenteral solutions is described. The unstable prodrug reacts quantitatively with the nucleophilic agent aniline by an unusual mechanism to form a phenylimino derivative of acronine. This derivative and acronine itself were determ...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1978-02, Vol.67 (2), p.237-239
Hauptverfasser:	Hansen, Anne Bagger, Kreilgård, Bo, Huang, Chong-Heng, Repta, A.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Acetylacroninium perchlorate-two-component spectrophotometric analysis with acronine in parenteral solutions Acronine - analogs & derivatives Acronine - analysis Acronine - chemical synthesis acronine and 7-acetylacroninium perchlorate in parenteral solutions Acronine-two-component spectrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions Alkaloids - analysis Antineoplastic agents-acronine Antineoplastic agents—acronine, two-component spestrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions Antineoplastic agents—acronine, two‐component spectrophotometric analysis with 7‐acetylacroninium perchlorate in parenteral solutions Chromatography, Thin Layer Drug Interactions Light Prodrugs-7-acetylacroninium perchlorate Prodrugs—7-acetylacroninium perchlorate, two-component spectrophotometric analysis with acronine in parenteral solutions Spectrophotometry Spectrophotometry-two-component analysis Spectrophotometry—two-component analysis, acronine and 7-acetylacroninium perchlorate in parenteral solutions two-component spectrophotometric analysis with 7-acetylacroninium perchlorate in parenteral solutions two-component spectrophotometric analysis with acronine in parenteral solutions
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Beschreibung
Zusammenfassung:	Analysis of acronine and the prodrug acetylacroninium perchlorate in parenteral solutions is described. The unstable prodrug reacts quantitatively with the nucleophilic agent aniline by an unusual mechanism to form a phenylimino derivative of acronine. This derivative and acronine itself were determined by a spectrophotometric two-component method.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600670228