Identification of Diacetylmorphine Metabolites in Humans

With the techniques of column chromatography, TLC, and GLC, morphine, 6-acetylmorphine, normorphine, morphine 3-glucuronide, 6-acetylmorphine 3-glucuronide, and normorphine glucuronide were identified as metabolites of diacetylmorphine (heroin) in the urine of humans administered 10mg iv/70kg body w...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1977-02, Vol.66 (2), p.201-204
Hauptverfasser:	Yeh, S.Y., McQuinn, R.L., Gorodetzky, C.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Cats Chromatography, Gas Chromatography, Ion Exchange Chromatography, Thin Layer Column chromatography-identification Column chromatography—identification diacetylmorphine metabolites, human urine D Diacetylmorphine-metabolites identified using TLC D Diacetylmorphine—metabolites identified using TLC, GLC and column chromatography, human urine diacetylmorphine metabolites Diacetylmorphine—metabolites identified using TLC GLC, and column chromatography, human urine Dogs GLC and column chromatography GLC-identification GLC—identification diacetylmorphine metabolites, human urine Glucuronates - urine Heroin - metabolism Heroin - urine human urine Humans Hydrolysis Hydromorphone - urine identified using TLC Male Mass Spectrometry metabolites identified using TLC Metabolites-dia cetylmorphine Metabolites—dia cetylmorphine, identified using TLC, GLC and column chromatography, human urine Metabolites—diaetylmorphine identified using TLC, GLC, and column chromatography, human urine Morphine Derivatives - urine Narcotics-diacetylmorphine Narcotics—diacetylmorphine metabolites identified using TLC, GLC, and column chromatography, human urine TLC-identification TLC—identification diacetylmorphine metabolites, human urine
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Zusammenfassung:	With the techniques of column chromatography, TLC, and GLC, morphine, 6-acetylmorphine, normorphine, morphine 3-glucuronide, 6-acetylmorphine 3-glucuronide, and normorphine glucuronide were identified as metabolites of diacetylmorphine (heroin) in the urine of humans administered 10mg iv/70kg body weight.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600660217