Clofibrate Microcapsules: Preparation and Release Rate Studies
Microencapsulation of clofibrate and dissolution characteristics of clofibrate microcapsules were investigated. Spherical droplets of clofibrate, prepared by a capillary jet method, were encapsulated in gelatin by simple coacervation, using sodium sulfate as the coacervating agent. The microcapsules...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1976-10, Vol.65 (10), p.1476-1479 |
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| container_end_page | 1479 |
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| container_issue | 10 |
| container_start_page | 1476 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 65 |
| creator | Madan, P.L. Madan, Devendra K. Price, J.C. |
| description | Microencapsulation of clofibrate and dissolution characteristics of clofibrate microcapsules were investigated. Spherical droplets of clofibrate, prepared by a capillary jet method, were encapsulated in gelatin by simple coacervation, using sodium sulfate as the coacervating agent. The microcapsules, which were hardened up to 8hr with formaldehyde, were recovered as discrete, free‐flowing particles. Dissolution of clofibrate from the microcapsules was not adequately described by either square root of time or Langenbucher kinetics but followed predominantly zero‐order release patterns at all hardening times. A linear correlation was found between the hardening time and the t50% release time. |
| doi_str_mv | 10.1002/jps.2600651015 |
| format | Article |
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Spherical droplets of clofibrate, prepared by a capillary jet method, were encapsulated in gelatin by simple coacervation, using sodium sulfate as the coacervating agent. The microcapsules, which were hardened up to 8hr with formaldehyde, were recovered as discrete, free‐flowing particles. Dissolution of clofibrate from the microcapsules was not adequately described by either square root of time or Langenbucher kinetics but followed predominantly zero‐order release patterns at all hardening times. A linear correlation was found between the hardening time and the t50% release time.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600651015</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>clofibrate ; Clofibrate-microcapsules prepared ; Clofibrate—microcapsules prepared, release rate studied ; Dosage forms-micròcapsules ; Dosage forms—micròcapsules, clofibrate, preparation described, release rate studied ; Hypocholesterolemic agents-clofibrate ; Hypocholesterolemic agents—clofibrate, microcapsules, preparation described, release rate studied ; microcapsules ; Microcapsules-clofibrate ; Microcapsules—clofibrate, preparation described, release rate studied ; preparation described ; release rate studied ; Release rate-clofibrate from microcapsules</subject><ispartof>Journal of pharmaceutical sciences, 1976-10, Vol.65 (10), p.1476-1479</ispartof><rights>1976 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1976 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4405-9ffafadef9955adad8dce4cdee896ae560d0878dd1021c9ab6f93be2eeb8ba2e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600651015$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600651015$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids></links><search><creatorcontrib>Madan, P.L.</creatorcontrib><creatorcontrib>Madan, Devendra K.</creatorcontrib><creatorcontrib>Price, J.C.</creatorcontrib><title>Clofibrate Microcapsules: Preparation and Release Rate Studies</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Microencapsulation of clofibrate and dissolution characteristics of clofibrate microcapsules were investigated. Spherical droplets of clofibrate, prepared by a capillary jet method, were encapsulated in gelatin by simple coacervation, using sodium sulfate as the coacervating agent. The microcapsules, which were hardened up to 8hr with formaldehyde, were recovered as discrete, free‐flowing particles. Dissolution of clofibrate from the microcapsules was not adequately described by either square root of time or Langenbucher kinetics but followed predominantly zero‐order release patterns at all hardening times. A linear correlation was found between the hardening time and the t50% release time.</description><subject>clofibrate</subject><subject>Clofibrate-microcapsules prepared</subject><subject>Clofibrate—microcapsules prepared, release rate studied</subject><subject>Dosage forms-micròcapsules</subject><subject>Dosage forms—micròcapsules, clofibrate, preparation described, release rate studied</subject><subject>Hypocholesterolemic agents-clofibrate</subject><subject>Hypocholesterolemic agents—clofibrate, microcapsules, preparation described, release rate studied</subject><subject>microcapsules</subject><subject>Microcapsules-clofibrate</subject><subject>Microcapsules—clofibrate, preparation described, release rate studied</subject><subject>preparation described</subject><subject>release rate studied</subject><subject>Release rate-clofibrate from microcapsules</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><recordid>eNqFkLFOwzAQhi0EEqWwMucFUuwkdmIGJBRBAbVQ2kJHy7HPkktoKjsF-va4CgIxIKYb7vtO_38InRI8IBgnZ8u1HyQMY0YJJnQP9QhNcMwwyfdRLwBJnNKMH6Ij75c4YJjSHroo68bYyskWorFVrlFy7Tc1-PNo4mAtw8I2q0iudDSFGqSHaLpjZ-1GW_DH6MDI2sPJ1-yjp-ureXkTjx6Gt-XlKFZZhmnMjZFGajCcUyq11IVWkCkNUHAmgTKscZEXWhOcEMVlxQxPK0gAqqKSCaR9NOjuhoTeOzBi7eyrdFtBsNi1F6G9-GkfBN4J77aG7T-0uJvMfrlx51rfwse3K92LYHmaU7G4H4pxnj8_lnMmFoEvOh7CB94sOOGVhZUCbR2oVujG_hXzE1FwgfM</recordid><startdate>197610</startdate><enddate>197610</enddate><creator>Madan, P.L.</creator><creator>Madan, Devendra K.</creator><creator>Price, J.C.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197610</creationdate><title>Clofibrate Microcapsules: Preparation and Release Rate Studies</title><author>Madan, P.L. ; Madan, Devendra K. ; Price, J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4405-9ffafadef9955adad8dce4cdee896ae560d0878dd1021c9ab6f93be2eeb8ba2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>clofibrate</topic><topic>Clofibrate-microcapsules prepared</topic><topic>Clofibrate—microcapsules prepared, release rate studied</topic><topic>Dosage forms-micròcapsules</topic><topic>Dosage forms—micròcapsules, clofibrate, preparation described, release rate studied</topic><topic>Hypocholesterolemic agents-clofibrate</topic><topic>Hypocholesterolemic agents—clofibrate, microcapsules, preparation described, release rate studied</topic><topic>microcapsules</topic><topic>Microcapsules-clofibrate</topic><topic>Microcapsules—clofibrate, preparation described, release rate studied</topic><topic>preparation described</topic><topic>release rate studied</topic><topic>Release rate-clofibrate from microcapsules</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Madan, P.L.</creatorcontrib><creatorcontrib>Madan, Devendra K.</creatorcontrib><creatorcontrib>Price, J.C.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Madan, P.L.</au><au>Madan, Devendra K.</au><au>Price, J.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clofibrate Microcapsules: Preparation and Release Rate Studies</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1976-10</date><risdate>1976</risdate><volume>65</volume><issue>10</issue><spage>1476</spage><epage>1479</epage><pages>1476-1479</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Microencapsulation of clofibrate and dissolution characteristics of clofibrate microcapsules were investigated. Spherical droplets of clofibrate, prepared by a capillary jet method, were encapsulated in gelatin by simple coacervation, using sodium sulfate as the coacervating agent. The microcapsules, which were hardened up to 8hr with formaldehyde, were recovered as discrete, free‐flowing particles. Dissolution of clofibrate from the microcapsules was not adequately described by either square root of time or Langenbucher kinetics but followed predominantly zero‐order release patterns at all hardening times. A linear correlation was found between the hardening time and the t50% release time.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><doi>10.1002/jps.2600651015</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1976-10, Vol.65 (10), p.1476-1479 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jps_2600651015 |
| source | Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | clofibrate Clofibrate-microcapsules prepared Clofibrate—microcapsules prepared, release rate studied Dosage forms-micròcapsules Dosage forms—micròcapsules, clofibrate, preparation described, release rate studied Hypocholesterolemic agents-clofibrate Hypocholesterolemic agents—clofibrate, microcapsules, preparation described, release rate studied microcapsules Microcapsules-clofibrate Microcapsules—clofibrate, preparation described, release rate studied preparation described release rate studied Release rate-clofibrate from microcapsules |
| title | Clofibrate Microcapsules: Preparation and Release Rate Studies |
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