Clofibrate Microcapsules: Preparation and Release Rate Studies

Microencapsulation of clofibrate and dissolution characteristics of clofibrate microcapsules were investigated. Spherical droplets of clofibrate, prepared by a capillary jet method, were encapsulated in gelatin by simple coacervation, using sodium sulfate as the coacervating agent. The microcapsules, which were hardened up to 8hr with formaldehyde, were recovered as discrete, free‐flowing particles. Dissolution of clofibrate from the microcapsules was not adequately described by either square root of time or Langenbucher kinetics but followed predominantly zero‐order release patterns at all hardening times. A linear correlation was found between the hardening time and the t50% release time.