Synthesis of 5‐Hydroxy‐1‐[[5‐(p‐nitrophenyl)furfurylidene]‐amino]Hydantoin, a Metabolite of Dantrolene

The synthesis and structural elucidation of 5‐hydroxy‐1‐[[5‐(p‐nitrophenyl)furfurylidene]amino]hydantoin, a compound proposed as a metabolite of dantrolene sodium, are reported. In addition, a chromatographic comparison of the biological and synthesized materials is made.

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Veröffentlicht in:	Journal of pharmaceutical sciences 1976-01, Vol.65 (1), p.135-136
Hauptverfasser:	White, Ralph L., Schwan, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxy-1-[[5-(p-nitrophenyl)furfurylidene]-amino]hydantoin-dantrolene metabclite 5‐Hydroxy‐1‐[[5‐(p‐nitrophenyl)furfurylidene]‐amino]hydantoin—dantrolene metabclite, synthesis and structural elucidation Dantrolene metabolite-synthesis and structural elucidation of 5-hydroxy-1-[[5-(p-nitrophenyl)furfurylidene]amino]hydantoin synthesis and structural elucidation
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Beschreibung
Zusammenfassung:	The synthesis and structural elucidation of 5‐hydroxy‐1‐[[5‐(p‐nitrophenyl)furfurylidene]amino]hydantoin, a compound proposed as a metabolite of dantrolene sodium, are reported. In addition, a chromatographic comparison of the biological and synthesized materials is made.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600650133