5‐Chloro‐2‐Pyrimidinyl Analog of Dantrolene

1{[5‐(5‐Chloro‐2‐pyrimidinyl)furfurylidene]amino}‐hydantoin, a structural analog of the skeletal muscle contraction antagonist dantrolene, was synthesized and found to have no skeletal muscle relaxant activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1975-02, Vol.64 (2), p.337-338
Hauptverfasser:	Schwan, Thomas J., Ellis, K.O.
Format:	Artikel
Sprache:	eng
Schlagworte:	1{[5-(5-Chloro- 2- pyrimidinyl)furfurylidene]amino}hydantoin-structural analog of dantrolene 1{[5‐(5‐Chloro‐ 2‐ pyrimidinyl)furfurylidene]amino}hydantoin—structural analog of dantrolene, synthesized and screened for muscle relaxant activity Animals Chlorine - pharmacology Dantrolen-synthesis and screening for muscle relaxant activity of 5-chloro-2-pyrimidinyl analog Dantrolene - analogs & derivatives Dantrolene - chemical synthesis Dose-Response Relationship, Drug Hydantoins - chemical synthesis In Vitro Techniques Mice Muscle Contraction - drug effects Muscle relaxant activity-5-chloro-2-pyrimidinyl analog of dantrolene Muscles - drug effects Pyrimidines - chemical synthesis Pyrimidines - pharmacology Rats synthesized and screened for muscle relaxant activity
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Beschreibung
Zusammenfassung:	1{[5‐(5‐Chloro‐2‐pyrimidinyl)furfurylidene]amino}‐hydantoin, a structural analog of the skeletal muscle contraction antagonist dantrolene, was synthesized and found to have no skeletal muscle relaxant activity.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600640234