Ability of certain additives to influence the absorption of salicylic acid from solutions in an in vivo study: Preliminary report

The influence of polysorbates, sucrose, polyethylene glycols (PEG), propylene glycol, and dimethylsulfoxide (DMSO) on the absorption of salicylic acid has been studied. An immersion technique utilizing the frog was used. Results were analyzed by the Student t test. Certain concentrations of additive...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1967-12, Vol.56 (12), p.1661-1663
Hauptverfasser:	Whitworth, Clyde W., Yantis, Loudon D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anura Biological Transport Dimethyl Sulfoxide - pharmacology Drug Synergism Fatty Acids - pharmacology Glycols - pharmacology Hydrogen-Ion Concentration Pharmaceutic Aids Propylene Glycols - pharmacology Salicylates - metabolism Skin Absorption - drug effects Solubility Solutions Spectrophotometry Statistics as Topic Sucrose - pharmacology Time Factors
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Zusammenfassung:	The influence of polysorbates, sucrose, polyethylene glycols (PEG), propylene glycol, and dimethylsulfoxide (DMSO) on the absorption of salicylic acid has been studied. An immersion technique utilizing the frog was used. Results were analyzed by the Student t test. Certain concentrations of additives were seen to enhance absorption.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600561227