Synthesis of 4-Substituted-7-methylpyrrolo[2,3-d]pyrimidines

Synthesis of 4-Substituted-7-methylpyrrolo[2,3-d]pyrimidines

The reactions of 4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine(IV) with ethanolic ammonia, thiourea, and aqueous sodium sulfhydrate solution to give the 4-amino(V) and 4-thione(VI) analogs are described. Ultraviolet data and pKa values for IV, V, and VI are reported.

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Veröffentlicht in:Journal of pharmaceutical sciences 1966-10, Vol.55 (10), p.1096-1098
1. Verfasser: Hammer, Richard H.
Format: Artikel
Sprache:eng
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Zusammenfassung:The reactions of 4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine(IV) with ethanolic ammonia, thiourea, and aqueous sodium sulfhydrate solution to give the 4-amino(V) and 4-thione(VI) analogs are described. Ultraviolet data and pKa values for IV, V, and VI are reported.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600551023