Dielectric Solubility Profiles of Acetanilide and Several Derivatives in Dioxane–Water Mixtures

The solubilities of acetanilide, p-methyl acetanilide, and p-ethoxyacetanilide (phenacetin) were determined in dioxane–water mixtures of known dielectric constants. The solubility curves that were obtained showed a multiplicity of peak solubility values as a function of the dielectric constant. These peak solubilities or dielectric requirements for the subject compounds were found to vary to some extent and may reflect solute polarity with respect to acetanilide as the parent compound.