Dissolution Rate Studies III. Penetration Model for Describing Dissolution of a Multiparticulate System

Danckwerts' penetration model is used to derive equations for the dissolution of solids in a multiparticulate system. The equations obtained are capable of explaining the deviations from linearity of cube-root plots. The loss of sensitivity in distinguishing differences between polymorph dissolution rates at high agitation intensities also may be rationalized from these equations.