Determination of m-Aminophenol (MAP) in Calcium Aminosalicylate [Ca(PAS)2]

The MAP test in the N.F. XI monograph for Ca(PAS)2 has been re-evaluated. Experimental data showed the test to be in need of minor changes to correct sources of error. Based on this study, recommendations are made to use sulfuric acid instead of hydrochloric acid, to change the correction factor, to...

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Veröffentlicht in:Journal of pharmaceutical sciences 1962-09, Vol.51 (9), p.910-911
Hauptverfasser: Luers, R.B., Stadler, L.B.
Format: Artikel
Sprache:eng
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Zusammenfassung:The MAP test in the N.F. XI monograph for Ca(PAS)2 has been re-evaluated. Experimental data showed the test to be in need of minor changes to correct sources of error. Based on this study, recommendations are made to use sulfuric acid instead of hydrochloric acid, to change the correction factor, to determine maximum absorbance through a range of 425 to 435 mμ and to change the time allowed for color development to 3 hours.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600510924