Biosynthese der Anthracycline: eine Neuinterpretation der Ergebnisse zur Daunomycin-Biosynthese

On the basis of literature data and our own experiments the “late” biosynthetic pathway to daunomycin has been interpreted from a new point of view considering both the in vivo biosynthesis and formation of shunt products. In contrast to existing hypotheses proposed by other authors we discuss a modified sequence leading to C‐11 oxidation and, as a consequence, understand ϵ‐rhodomycinone as a shunt product instead of a biosynthetic intermediate. In addition, a new hypothesis about the “early” steps of the ring formation from polyketides by a sequence of enzyme reactions has been proposed.