Comparison of Free-Breathing 3D Phase-Resolved Functional Lung (PREFUL) MRI With Dynamic 19 F Ventilation MRI in Patients With Obstructive Lung Disease and Healthy Volunteers
Non-contrast-enhanced H magnetic resonance imaging (MRI) with full lung coverage shows promise for assessment of regional lung ventilation but a comparison with direct ventilation measurement using F MRI is lacking. To compare ventilation parameters calculated using 3D phase-resolved functional lung...
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creator | Klimeš, Filip Obert, Arnd J Scheller, Julienne Wernz, Marius M Voskrebenzev, Andreas Gutberlet, Marcel Grimm, Robert Suhling, Hendrik Müller, Robin A Kaireit, Till F Glandorf, Julian Moher Alsady, Tawfik Wacker, Frank Vogel-Claussen, Jens |
description | Non-contrast-enhanced
H magnetic resonance imaging (MRI) with full lung coverage shows promise for assessment of regional lung ventilation but a comparison with direct ventilation measurement using
F MRI is lacking.
To compare ventilation parameters calculated using 3D phase-resolved functional lung (PREFUL) MRI with
F MRI.
Prospective.
Fifteen patients with asthma, 14 patients with chronic obstructive lung disease, and 13 healthy volunteers.
A 3D gradient-echo pulse sequence with golden-angle increment and stack-of-stars encoding at 1.5 T.
All participants underwent 3D PREFUL MRI and
F MRI. For 3D PREFUL, static regional ventilation (RVent) and dynamic flow-volume cross-correlation metric (FVL-CM) were calculated. For both parameters, ventilation defect percentage (VDP) values and ventilation defect (VD) maps (including a combination of both parameters [VDP
]) were determined. For
F MRI, images from eight consecutive breaths under volume-controlled inhalation of perfluoropropane were acquired. Time-to-fill (TTF) and wash-in (WI) parameters were extracted. For all
F parameters, a VD map was generated and the corresponding VDP values were calculated.
For all parameters, the relationship between the two techniques was assessed using a Spearman correlation (r). Differences between VDP values were compared using Bland-Altman analysis. For regional comparison of VD maps, spatial overlap and Sørensen-Dice coefficients were computed.
3D PREFUL VDP values were significantly correlated to VDP measures by
F (r range: 0.59-0.70). For VDP
, no significant bias was observed with VDP of the third and fourth breath (bias range = -6.8:7.7%, P range = 0.25:0.30). For VDP
, no significant bias was found with VDP values of fourth-eighth breaths (bias range = -2.0:12.5%, P range = 0.12:0.75). The overall spatial overlap of all VD maps increased with each breath, ranging from 61% to 81%, stabilizing at the fourth breath.
3D PREFUL MRI parameters showed moderate to strong correlation with
F MRI. Depending on the 3D PREFUL VD map, the best regional agreement was found to
F VD maps of third-fifth breath.
3 TECHNICAL EFFICACY: Stage 2. |
doi_str_mv | 10.1002/jmri.29221 |
format | Article |
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H magnetic resonance imaging (MRI) with full lung coverage shows promise for assessment of regional lung ventilation but a comparison with direct ventilation measurement using
F MRI is lacking.
To compare ventilation parameters calculated using 3D phase-resolved functional lung (PREFUL) MRI with
F MRI.
Prospective.
Fifteen patients with asthma, 14 patients with chronic obstructive lung disease, and 13 healthy volunteers.
A 3D gradient-echo pulse sequence with golden-angle increment and stack-of-stars encoding at 1.5 T.
All participants underwent 3D PREFUL MRI and
F MRI. For 3D PREFUL, static regional ventilation (RVent) and dynamic flow-volume cross-correlation metric (FVL-CM) were calculated. For both parameters, ventilation defect percentage (VDP) values and ventilation defect (VD) maps (including a combination of both parameters [VDP
]) were determined. For
F MRI, images from eight consecutive breaths under volume-controlled inhalation of perfluoropropane were acquired. Time-to-fill (TTF) and wash-in (WI) parameters were extracted. For all
F parameters, a VD map was generated and the corresponding VDP values were calculated.
For all parameters, the relationship between the two techniques was assessed using a Spearman correlation (r). Differences between VDP values were compared using Bland-Altman analysis. For regional comparison of VD maps, spatial overlap and Sørensen-Dice coefficients were computed.
3D PREFUL VDP values were significantly correlated to VDP measures by
F (r range: 0.59-0.70). For VDP
, no significant bias was observed with VDP of the third and fourth breath (bias range = -6.8:7.7%, P range = 0.25:0.30). For VDP
, no significant bias was found with VDP values of fourth-eighth breaths (bias range = -2.0:12.5%, P range = 0.12:0.75). The overall spatial overlap of all VD maps increased with each breath, ranging from 61% to 81%, stabilizing at the fourth breath.
3D PREFUL MRI parameters showed moderate to strong correlation with
F MRI. Depending on the 3D PREFUL VD map, the best regional agreement was found to
F VD maps of third-fifth breath.
3 TECHNICAL EFFICACY: Stage 2.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.29221</identifier><identifier>PMID: 38214459</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Asthma - diagnostic imaging ; Female ; Healthy Volunteers ; Humans ; Imaging, Three-Dimensional ; Lung - diagnostic imaging ; Lung Diseases, Obstructive - diagnostic imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive - diagnostic imaging ; Pulmonary Ventilation ; Respiration</subject><ispartof>Journal of magnetic resonance imaging, 2024-10, Vol.60 (4), p.1416-1431</ispartof><rights>2024 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c999-fd3abd3cfec50fb25b27516f20e1cc78d3f2a22e47f545fb30b1ed40d0ad923</citedby><cites>FETCH-LOGICAL-c999-fd3abd3cfec50fb25b27516f20e1cc78d3f2a22e47f545fb30b1ed40d0ad923</cites><orcidid>0000-0002-6164-8973 ; 0000-0003-1927-9876 ; 0000-0003-4007-4904 ; 0000-0003-2715-0757 ; 0000-0002-0779-0688 ; 0009-0003-0452-8574 ; 0000-0001-9786-2026 ; 0000-0001-5595-6948</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38214459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klimeš, Filip</creatorcontrib><creatorcontrib>Obert, Arnd J</creatorcontrib><creatorcontrib>Scheller, Julienne</creatorcontrib><creatorcontrib>Wernz, Marius M</creatorcontrib><creatorcontrib>Voskrebenzev, Andreas</creatorcontrib><creatorcontrib>Gutberlet, Marcel</creatorcontrib><creatorcontrib>Grimm, Robert</creatorcontrib><creatorcontrib>Suhling, Hendrik</creatorcontrib><creatorcontrib>Müller, Robin A</creatorcontrib><creatorcontrib>Kaireit, Till F</creatorcontrib><creatorcontrib>Glandorf, Julian</creatorcontrib><creatorcontrib>Moher Alsady, Tawfik</creatorcontrib><creatorcontrib>Wacker, Frank</creatorcontrib><creatorcontrib>Vogel-Claussen, Jens</creatorcontrib><title>Comparison of Free-Breathing 3D Phase-Resolved Functional Lung (PREFUL) MRI With Dynamic 19 F Ventilation MRI in Patients With Obstructive Lung Disease and Healthy Volunteers</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Non-contrast-enhanced
H magnetic resonance imaging (MRI) with full lung coverage shows promise for assessment of regional lung ventilation but a comparison with direct ventilation measurement using
F MRI is lacking.
To compare ventilation parameters calculated using 3D phase-resolved functional lung (PREFUL) MRI with
F MRI.
Prospective.
Fifteen patients with asthma, 14 patients with chronic obstructive lung disease, and 13 healthy volunteers.
A 3D gradient-echo pulse sequence with golden-angle increment and stack-of-stars encoding at 1.5 T.
All participants underwent 3D PREFUL MRI and
F MRI. For 3D PREFUL, static regional ventilation (RVent) and dynamic flow-volume cross-correlation metric (FVL-CM) were calculated. For both parameters, ventilation defect percentage (VDP) values and ventilation defect (VD) maps (including a combination of both parameters [VDP
]) were determined. For
F MRI, images from eight consecutive breaths under volume-controlled inhalation of perfluoropropane were acquired. Time-to-fill (TTF) and wash-in (WI) parameters were extracted. For all
F parameters, a VD map was generated and the corresponding VDP values were calculated.
For all parameters, the relationship between the two techniques was assessed using a Spearman correlation (r). Differences between VDP values were compared using Bland-Altman analysis. For regional comparison of VD maps, spatial overlap and Sørensen-Dice coefficients were computed.
3D PREFUL VDP values were significantly correlated to VDP measures by
F (r range: 0.59-0.70). For VDP
, no significant bias was observed with VDP of the third and fourth breath (bias range = -6.8:7.7%, P range = 0.25:0.30). For VDP
, no significant bias was found with VDP values of fourth-eighth breaths (bias range = -2.0:12.5%, P range = 0.12:0.75). The overall spatial overlap of all VD maps increased with each breath, ranging from 61% to 81%, stabilizing at the fourth breath.
3D PREFUL MRI parameters showed moderate to strong correlation with
F MRI. Depending on the 3D PREFUL VD map, the best regional agreement was found to
F VD maps of third-fifth breath.
3 TECHNICAL EFFICACY: Stage 2.</description><subject>Adult</subject><subject>Aged</subject><subject>Asthma - diagnostic imaging</subject><subject>Female</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Lung - diagnostic imaging</subject><subject>Lung Diseases, Obstructive - diagnostic imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</subject><subject>Pulmonary Ventilation</subject><subject>Respiration</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1PwjAUhhuj8QO98QeYXqrJsB-r0EsFJiYYCFG8XLr1VEq2jrQbCX_K3-gA9ep85DnvSR6ErinpUkLYw6r0tsskY_QInVPBWMRE__G47YngEe2T3hm6CGFFCJEyFqfojPcZjWMhz9H3oCrXyttQOVwZnHiA6NmDqpfWfWE-xLOlChDNIVTFBjROGpfXtnKqwJOmJW5n81HyMbnDb_NX_GnrJR5unSptjqnECV6Aq22hdhd7wjo8a6d2Gw70NAu1b9rIDRwChzZA-xErp_EYVFEvt3hRFY2rAXy4RCdGFQGufmsHzZPR-2AcTaYvr4OnSZRLKSOjuco0zw3kgpiMiYz1BH00jADN815fc8MUYxD3jIiFyTjJKOiYaKK0ZLyD7g-hua9C8GDStbel8tuUknRnPN0ZT_fGW_jmAK-brAT9j_4p5j8WG336</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Klimeš, Filip</creator><creator>Obert, Arnd J</creator><creator>Scheller, Julienne</creator><creator>Wernz, Marius M</creator><creator>Voskrebenzev, Andreas</creator><creator>Gutberlet, Marcel</creator><creator>Grimm, Robert</creator><creator>Suhling, Hendrik</creator><creator>Müller, Robin A</creator><creator>Kaireit, Till F</creator><creator>Glandorf, Julian</creator><creator>Moher Alsady, Tawfik</creator><creator>Wacker, Frank</creator><creator>Vogel-Claussen, Jens</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-6164-8973</orcidid><orcidid>https://orcid.org/0000-0003-1927-9876</orcidid><orcidid>https://orcid.org/0000-0003-4007-4904</orcidid><orcidid>https://orcid.org/0000-0003-2715-0757</orcidid><orcidid>https://orcid.org/0000-0002-0779-0688</orcidid><orcidid>https://orcid.org/0009-0003-0452-8574</orcidid><orcidid>https://orcid.org/0000-0001-9786-2026</orcidid><orcidid>https://orcid.org/0000-0001-5595-6948</orcidid></search><sort><creationdate>202410</creationdate><title>Comparison of Free-Breathing 3D Phase-Resolved Functional Lung (PREFUL) MRI With Dynamic 19 F Ventilation MRI in Patients With Obstructive Lung Disease and Healthy Volunteers</title><author>Klimeš, Filip ; Obert, Arnd J ; Scheller, Julienne ; Wernz, Marius M ; Voskrebenzev, Andreas ; Gutberlet, Marcel ; Grimm, Robert ; Suhling, Hendrik ; Müller, Robin A ; Kaireit, Till F ; Glandorf, Julian ; Moher Alsady, Tawfik ; Wacker, Frank ; Vogel-Claussen, Jens</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c999-fd3abd3cfec50fb25b27516f20e1cc78d3f2a22e47f545fb30b1ed40d0ad923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Asthma - diagnostic imaging</topic><topic>Female</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Lung - diagnostic imaging</topic><topic>Lung Diseases, Obstructive - diagnostic imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</topic><topic>Pulmonary Ventilation</topic><topic>Respiration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klimeš, Filip</creatorcontrib><creatorcontrib>Obert, Arnd J</creatorcontrib><creatorcontrib>Scheller, Julienne</creatorcontrib><creatorcontrib>Wernz, Marius M</creatorcontrib><creatorcontrib>Voskrebenzev, Andreas</creatorcontrib><creatorcontrib>Gutberlet, Marcel</creatorcontrib><creatorcontrib>Grimm, Robert</creatorcontrib><creatorcontrib>Suhling, Hendrik</creatorcontrib><creatorcontrib>Müller, Robin A</creatorcontrib><creatorcontrib>Kaireit, Till F</creatorcontrib><creatorcontrib>Glandorf, Julian</creatorcontrib><creatorcontrib>Moher Alsady, Tawfik</creatorcontrib><creatorcontrib>Wacker, Frank</creatorcontrib><creatorcontrib>Vogel-Claussen, Jens</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klimeš, Filip</au><au>Obert, Arnd J</au><au>Scheller, Julienne</au><au>Wernz, Marius M</au><au>Voskrebenzev, Andreas</au><au>Gutberlet, Marcel</au><au>Grimm, Robert</au><au>Suhling, Hendrik</au><au>Müller, Robin A</au><au>Kaireit, Till F</au><au>Glandorf, Julian</au><au>Moher Alsady, Tawfik</au><au>Wacker, Frank</au><au>Vogel-Claussen, Jens</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Free-Breathing 3D Phase-Resolved Functional Lung (PREFUL) MRI With Dynamic 19 F Ventilation MRI in Patients With Obstructive Lung Disease and Healthy Volunteers</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2024-10</date><risdate>2024</risdate><volume>60</volume><issue>4</issue><spage>1416</spage><epage>1431</epage><pages>1416-1431</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Non-contrast-enhanced
H magnetic resonance imaging (MRI) with full lung coverage shows promise for assessment of regional lung ventilation but a comparison with direct ventilation measurement using
F MRI is lacking.
To compare ventilation parameters calculated using 3D phase-resolved functional lung (PREFUL) MRI with
F MRI.
Prospective.
Fifteen patients with asthma, 14 patients with chronic obstructive lung disease, and 13 healthy volunteers.
A 3D gradient-echo pulse sequence with golden-angle increment and stack-of-stars encoding at 1.5 T.
All participants underwent 3D PREFUL MRI and
F MRI. For 3D PREFUL, static regional ventilation (RVent) and dynamic flow-volume cross-correlation metric (FVL-CM) were calculated. For both parameters, ventilation defect percentage (VDP) values and ventilation defect (VD) maps (including a combination of both parameters [VDP
]) were determined. For
F MRI, images from eight consecutive breaths under volume-controlled inhalation of perfluoropropane were acquired. Time-to-fill (TTF) and wash-in (WI) parameters were extracted. For all
F parameters, a VD map was generated and the corresponding VDP values were calculated.
For all parameters, the relationship between the two techniques was assessed using a Spearman correlation (r). Differences between VDP values were compared using Bland-Altman analysis. For regional comparison of VD maps, spatial overlap and Sørensen-Dice coefficients were computed.
3D PREFUL VDP values were significantly correlated to VDP measures by
F (r range: 0.59-0.70). For VDP
, no significant bias was observed with VDP of the third and fourth breath (bias range = -6.8:7.7%, P range = 0.25:0.30). For VDP
, no significant bias was found with VDP values of fourth-eighth breaths (bias range = -2.0:12.5%, P range = 0.12:0.75). The overall spatial overlap of all VD maps increased with each breath, ranging from 61% to 81%, stabilizing at the fourth breath.
3D PREFUL MRI parameters showed moderate to strong correlation with
F MRI. Depending on the 3D PREFUL VD map, the best regional agreement was found to
F VD maps of third-fifth breath.
3 TECHNICAL EFFICACY: Stage 2.</abstract><cop>United States</cop><pmid>38214459</pmid><doi>10.1002/jmri.29221</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-6164-8973</orcidid><orcidid>https://orcid.org/0000-0003-1927-9876</orcidid><orcidid>https://orcid.org/0000-0003-4007-4904</orcidid><orcidid>https://orcid.org/0000-0003-2715-0757</orcidid><orcidid>https://orcid.org/0000-0002-0779-0688</orcidid><orcidid>https://orcid.org/0009-0003-0452-8574</orcidid><orcidid>https://orcid.org/0000-0001-9786-2026</orcidid><orcidid>https://orcid.org/0000-0001-5595-6948</orcidid></addata></record> |
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source | MEDLINE; Access via Wiley Online Library |
subjects | Adult Aged Asthma - diagnostic imaging Female Healthy Volunteers Humans Imaging, Three-Dimensional Lung - diagnostic imaging Lung Diseases, Obstructive - diagnostic imaging Magnetic Resonance Imaging - methods Male Middle Aged Prospective Studies Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Ventilation Respiration |
title | Comparison of Free-Breathing 3D Phase-Resolved Functional Lung (PREFUL) MRI With Dynamic 19 F Ventilation MRI in Patients With Obstructive Lung Disease and Healthy Volunteers |
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