Value of T 2 Mapping MRI for Prostate Cancer Detection and Classification

Currently, multi-parametric prostate MRI (mpMRI) consists of a qualitative T , diffusion weighted, and dynamic contrast enhanced imaging. Quantification of T imaging might further standardize PCa detection and support artificial intelligence solutions. To evaluate the value of T mapping to detect prostate cancer (PCa) and to differentiate PCa aggressiveness. Retrospective single center cohort study. Forty-four consecutive patients (mean age 67 years; median PSA 7.9 ng/mL) with mpMRI and verified PCa by subsequent targeted plus systematic MR/ultrasound (US)-fusion biopsy from February 2019 to December 2019. Standardized mpMRI at 3 T with an additionally acquired T mapping sequence. Primary endpoint was the analysis of quantitative T values and contrast differences/ratios (CD/CR) between PCa and benign tissue. Secondary objectives were the correlation between T values, ISUP grade, apparent diffusion coefficient (ADC) value, and PI-RADS, and the evaluation of thresholds for differentiating PCa and clinically significant PCa (csPCa). Mann-Whitney test, Spearman's rank (r ) correlation, receiver operating curves, Youden's index (J), and AUC were performed. Statistical significance was defined as P