Synthesis of 2 H‐ and 3 H‐labelled iptakalim hydrochloride

Synthesis of 2 H‐ and 3 H‐labelled iptakalim hydrochloride

Iptakalim hydrochloride ( N ‐(1‐methylethyl)‐1,1,2‐trimethyl‐propylamine hydrochloride) is a promising antihypertensive drug discovered and developed by Beijing Institute of Pharmacology and Toxicology. Deuterium‐ and tritium‐labelled compounds were designed and synthesized for pharmacokinetic and p...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 2004-08, Vol.47 (9), p.583-590
Hauptverfasser: Zhang, Cheng, Yang, Rifang, Chen, Lanfu, Zhong, Bohua, Yun, Liuhong, Wang, Hai
Format: Artikel
Sprache:eng
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Zusammenfassung:Iptakalim hydrochloride ( N ‐(1‐methylethyl)‐1,1,2‐trimethyl‐propylamine hydrochloride) is a promising antihypertensive drug discovered and developed by Beijing Institute of Pharmacology and Toxicology. Deuterium‐ and tritium‐labelled compounds were designed and synthesized for pharmacokinetic and pharmacological mechanism studies. A derivatization method has been employed in the synthesis procedure. Copyright © 2004 John Wiley & Sons, Ltd.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.844