Synthesis of [3′‐ 14 C] coenzyme Q 10

Synthesis of [3′‐ 14 C] coenzyme Q 10

Radio‐labelled coenzyme Q 10 , labelled at the 3′‐position with 14 C, was synthesized starting from natural solanesol and ethyl [3‐ 14 C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3‐ 14 C] acetoacetate. The specific radioactivity of the product was 44.8 μCi, 1.66 MBq/mg. The specifi...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 2002-09, Vol.45 (10), p.823-829
Hauptverfasser: Hamamura, Kimio, Yamatsu, Isao, Minami, Norio, Yamagishi, Yoji, Inai, Yuichi, Kijima, Shizumasa, Nakamura, Tetsuya
Format: Artikel
Sprache:eng
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Zusammenfassung:Radio‐labelled coenzyme Q 10 , labelled at the 3′‐position with 14 C, was synthesized starting from natural solanesol and ethyl [3‐ 14 C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3‐ 14 C] acetoacetate. The specific radioactivity of the product was 44.8 μCi, 1.66 MBq/mg. The specific radioactivity and radiochemical purity are sufficiently high to enable us to use this labelled form of coenzyme Q 10 in metabolic studies. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.588