Synthesis of 5-methylthioribose specifically bitritiated at the 5-C position

An efficient and reliable method for the preparation of bitritiated‐methylthioribose from a suitably protected 5‐ketoazido‐ribose derivative has been developed. This compound is an essential component in the assay of the microbial enzyme methylthioribose kinase, which is involved in the methionine s...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 2001-08, Vol.44 (9), p.653-659
Hauptverfasser:	Viegas, Christina, Zhang, Qiang, Guillerm, Danielle, Guillerm, Georges
Format:	Artikel
Sprache:	eng
Schlagworte:	3H labelling Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides Carbohydrates. Nucleosides and nucleotides Chemistry enzymatic assay Exact sciences and technology methylthioribose methylthioribose kinase Organic chemistry Preparations and properties
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Beschreibung
Zusammenfassung:	An efficient and reliable method for the preparation of bitritiated‐methylthioribose from a suitably protected 5‐ketoazido‐ribose derivative has been developed. This compound is an essential component in the assay of the microbial enzyme methylthioribose kinase, which is involved in the methionine salvage pathway from methylthioadenosine. Copyright © 2001 John Wiley & Sons, Ltd.
ISSN:	0362-4803 1099-1344
DOI:	10.1002/jlcr.498