Studies on the tritium labelling of some local anaesthetics and amino acids by the microwave discharge modification of the Wilzbach technique

Some local anaesthetics and amino acids were labelled with tritium by the microwave discharge modification of the Wilzbach technique. The following substances were investigated: local anaesthetics: carbocaine, citanest, l‐cocaine, tetracaine and xylocaine; amino acids: glycine, DL‐α‐alanine, DL‐Leuc...

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Veröffentlicht in:Journal of Labelled Compounds 1966-04, Vol.2 (2), p.155-173
Hauptverfasser: Gosztonyi, T., Walde, N.
Format: Artikel
Sprache:eng
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Zusammenfassung:Some local anaesthetics and amino acids were labelled with tritium by the microwave discharge modification of the Wilzbach technique. The following substances were investigated: local anaesthetics: carbocaine, citanest, l‐cocaine, tetracaine and xylocaine; amino acids: glycine, DL‐α‐alanine, DL‐Leucine, DL‐phenylalanine and DL‐tryptophane. The range of microwave energy used was 4,000 to 270,000 Wsec. The range of specific activities obtained was from 0.2 to 29.4 mC/mM; and for the most used substance, DL‐leucine, from 0.4 to 27.2 mC/mM. The effects of some reaction parameters on the labelling were investigated. Results obtained are discussed.
ISSN:0022-2135
1099-1344
DOI:10.1002/jlcr.2590020204