The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

The synthesis of the C‐14 labeled isotopomer of LY300502, a potent 5α‐reductase inhibitor has been accomplished in four radiochemical steps. The route involves the synthesis of LY300502‐[14C] from LY300502 via a circuitous route; the label was introduced with ethyl chloroformate‐[carbonyl‐14C]....

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1994-10, Vol.34 (10), p.915-920
Hauptverfasser: Kuo, Fengjiun, Wheeler, William J.
Format: Artikel
Sprache:eng
Schlagworte:
carbon 14
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
LY300502
Organic chemistry
Preparations and properties
selective type I5α-reductase inhibitor
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Zusammenfassung:The synthesis of the C‐14 labeled isotopomer of LY300502, a potent 5α‐reductase inhibitor has been accomplished in four radiochemical steps. The route involves the synthesis of LY300502‐[14C] from LY300502 via a circuitous route; the label was introduced with ethyl chloroformate‐[carbonyl‐14C].
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580341004