A practical approach to the synthesis of 14 C‐labeled amino acid and simple peptide
A convenient method for the synthesis of phenylmethyl N‐methyl ( carboxy ‐ 14 C) glycine hydrochloride (Z) is described. It involves the carboxylation of transmetalated organostannane compound 4 which itself is accessible by established procedure. Success in preparing the labelled amino acid Z enabl...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 1994-02, Vol.34 (2), p.107-115 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A convenient method for the synthesis of phenylmethyl N‐methyl (
carboxy
‐
14
C) glycine hydrochloride (Z) is described. It involves the carboxylation of transmetalated organostannane compound
4
which itself is accessible by established procedure. Success in preparing the labelled amino acid Z enabled us to synthesize target N‐glycyl‐N‐methyl(
carboxy
‐
14
C) glycine (
10
) by conventional coupling protocol. |
|---|---|
| ISSN: | 0362-4803 1099-1344 |
| DOI: | 10.1002/jlcr.2580340202 |