Synthesis of the anti-tumor agent CI-973 {[SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2)](2-methyl-1,4-[4-14C]butanediamine-N,N′)platinum}

Starting from the chiral compound 1, (R)‐(+)‐2‐methyl‐1,4‐[14C]butanediamine 7 was synthesized in a sequence of reactions in which 14C‐label was introduce using label potassium cyanide. Compound 7 was reacted with potassium tetraiodoplatinate and silver 1,1‐cyclobutanedicarboxylate to make the title...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 1993-12, Vol.33 (12), p.1083-1089
Hauptverfasser:	Ekhato, I. Victor, Hoeschele, James D., Huang, Che C., Nanavaty, Bela, Lee, Helen T.
Format:	Artikel
Sprache:	eng
Schlagworte:	(R)-(+)-2-methyl-1 (R)‐(+)‐2‐methyl‐1,4‐butanediamine, antitumor drug, silver 1,1‐cyclobutanedicarboxylate 1-cyclobutanedicarboxylate 1-cyclobutanedicarboxylato](2-methyl-1 4-butane-N 4-butanediamine [SP-4-3-(R)]- [SP‐4‐3‐(R)]‐[1,1‐cyclobutanedicarboxylato](2‐methyl‐1,4‐butane‐N,N′)platinum antitumor drug Chemistry Coordination compounds Exact sciences and technology Inorganic chemistry and origins of life N′)platinum Preparations and properties silver 1 square-planar diaminoplatinum chelate complex
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Zusammenfassung:	Starting from the chiral compound 1, (R)‐(+)‐2‐methyl‐1,4‐[14C]butanediamine 7 was synthesized in a sequence of reactions in which 14C‐label was introduce using label potassium cyanide. Compound 7 was reacted with potassium tetraiodoplatinate and silver 1,1‐cyclobutanedicarboxylate to make the title compound {[SP‐4‐3‐(R)]‐[1,1‐cyclobutanedicarboxylato(2)](2‐methyl‐1,4‐butanediamine‐N,N′)platinum} 11.
ISSN:	0362-4803 1099-1344
DOI:	10.1002/jlcr.2580331202