A synthetic approach to carbon-14 labeled anti-bacterial napthyridine and quinolone carboxylic acids

Labeled versions of (S)‐clinafloxacin (1) and two naphthyridine carboxylic acid anti‐bacterial compounds 2 and 3 which are currently in development were synthesized. Preparations started from hitherto unknown bromo compounds 22 and 10, from which the corresponding 14C‐labeled aromatic carboxylic aci...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 1993-09, Vol.33 (9), p.869-880
Hauptverfasser:	Ekhato, I. Victor, Huang, Che C.
Format:	Artikel
Sprache:	eng
Schlagworte:	14C-labeled antibacterial naphthyridine and quinolone carboxylic acids
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Labeled versions of (S)‐clinafloxacin (1) and two naphthyridine carboxylic acid anti‐bacterial compounds 2 and 3 which are currently in development were synthesized. Preparations started from hitherto unknown bromo compounds 22 and 10, from which the corresponding 14C‐labeled aromatic carboxylic acids 23 and 12 were generated by metal‐halogen exchange followed by carboxylation reaction. Details of these preparations are given.
ISSN:	0362-4803 1099-1344
DOI:	10.1002/jlcr.2580330911