Synthesis of 2 H 8 ‐leukotriene B 4
A semi‐synthetic method for the preparation of deuterated leukotriene B 4 ( 2 H 8 ‐LTB 4 ) from eicosatetraynoic acid (ETYA) is described which involves reduction of ETYA to deuterated arachidonic acid ( 2 H 8 ‐AA) with deuterium gas and then biological conversion of this material to 2 H 8 ‐LTB 4 by...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 1987-03, Vol.24 (3), p.291-296 |
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| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A semi‐synthetic method for the preparation of deuterated leukotriene B
4
(
2
H
8
‐LTB
4
) from eicosatetraynoic acid (ETYA) is described which involves reduction of ETYA to deuterated arachidonic acid (
2
H
8
‐AA) with deuterium gas and then biological conversion of this material to
2
H
8
‐LTB
4
by rat peritoneal polymorphonuclear leukocytes (PMNs). |
|---|---|
| ISSN: | 0362-4803 1099-1344 |
| DOI: | 10.1002/jlcr.2580240308 |