Synthesis of labelled nordihydroguaiaretic acid

Meso‐2,3‐Dimethyl‐1,4‐bis(3,4‐dihydroxyphenyl)bytane‐1‐14C, (mesonordihydroguaiaretic acid‐1‐14C, NDGA‐1‐14C), was prepared. meso‐2,3‐Dimethyl‐1‐1,4‐bis (3,4‐dihydroxy‐2,5,6‐trideuterophenyl)butane (NDGA‐d6, ring labelled) was made from acid exchange of unlabelled natural product and meso 2,3‐dimethyl‐1,4‐bis(3,4‐dihydroxyphenyl)‐1,1,2,3,4,4‐hexadeuterobutane (NDGA‐d6, chain labelled) was prepared from hydrogenation of 3,4‐dimethyl‐2,5‐bis‐(3, 4‐dimethoxyphenyl)furan using deuterium and Pd/C catalyst.