synthesis of 10-[3H]-5H-dibenz[b, f] azepine-5-carboxamide ([3H]-carbamazepine)

synthesis of 10-[3H]-5H-dibenz[b, f] azepine-5-carboxamide ([3H]-carbamazepine)

The title compound has been prepared from a bromo derivative at a specific activity of 27 Ci mmol−1 with radiochemical purity of 98.4% by a selective catalytic reduction with tritium gas. Bromine was replaced without reduction of the stilbene double bond using a poisoned, deactivated catalyst.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1985-01, Vol.22 (1), p.37-41
1. Verfasser: Brundish, D. E.
Format: Artikel
Sprache:eng
Schlagworte:
Carbamazepine
selective reduction
tritiation
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Beschreibung
Zusammenfassung:The title compound has been prepared from a bromo derivative at a specific activity of 27 Ci mmol−1 with radiochemical purity of 98.4% by a selective catalytic reduction with tritium gas. Bromine was replaced without reduction of the stilbene double bond using a poisoned, deactivated catalyst.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580220106