Synthesis of N-[2-3H] acetyl-D-muramyl-L-alanyl-D-iso-glutaminyl-L-alanyl-2-(1′,2′-dipalmitoyl -sn-glycero-3′-phosphoryl) ethylamide of high specific radioactivity

Synthesis of N-[2-3H] acetyl-D-muramyl-L-alanyl-D-iso-glutaminyl-L-alanyl-2-(1′,2′-dipalmitoyl -sn-glycero-3′-phosphoryl) ethylamide of high specific radioactivity

The title compound (MTP‐cephalin) was synthesised with specific activity of 22 Ci mmol−1 and with radiochemical purity of 96–98% by a direct radiochemical synthesis using [3H] muramyl dipeptide. Several unsuccessful approaches to the target compound are documented.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1985-01, Vol.22 (1), p.29-35
Hauptverfasser: Brundish, D. E., Wade, R.
Format: Artikel
Sprache:eng
Schlagworte:
CGP 19835
immune modulator
MTP-cephalin
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Beschreibung
Zusammenfassung:The title compound (MTP‐cephalin) was synthesised with specific activity of 22 Ci mmol−1 and with radiochemical purity of 96–98% by a direct radiochemical synthesis using [3H] muramyl dipeptide. Several unsuccessful approaches to the target compound are documented.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580220105