Synthesis of 2,4′,5-trichloro [14C]biphenyl mercapturic acids

Synthesis of 2,4′,5-trichloro [14C]biphenyl mercapturic acids

The synthesis of 3‐ and 4‐S‐(N‐acetyl)cysteinyl‐2,4′,5‐trichloro[14C]biphenyl is described. 4‐Chloro[14C]aniline was used as starting material. The products were obtained after an aryl coupling of the amine with 2,5‐dichloronitrobenzene, a reduction of the nitrogroup and finally coupling of the diaz...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1983-08, Vol.20 (8), p.961-966
Hauptverfasser: Bergman, Ake, Bakke, Jerome E., Feil, Vernon J.
Format: Artikel
Sprache:eng
Schlagworte:
2,4′,5‐trichlorobiphenyl
5-trichlorobiphenyl
isotopes
mercapturic acids
metabolites
PCB
radiosynthesis
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Zusammenfassung:The synthesis of 3‐ and 4‐S‐(N‐acetyl)cysteinyl‐2,4′,5‐trichloro[14C]biphenyl is described. 4‐Chloro[14C]aniline was used as starting material. The products were obtained after an aryl coupling of the amine with 2,5‐dichloronitrobenzene, a reduction of the nitrogroup and finally coupling of the diazotized trichlorobiphenyl amine with cuprous N‐acetylcysteine mercaptide.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580200806