Quality control procedures in the preparation of 2-deoxy-D-[1-11C] glucose radiopharmaceutical

Preparation and quality control of 2‐deoxy‐D‐[1‐11C] glucose (11C‐2DG, 1) have been accomplished by a combination of cation‐exchange and high performance liquid chromatography (HPLC) to give the radiopharmaceutical in greater than 99% radiochemical purity and an overall 25‐35% radiochemical yield in 45‐50 min. Quality control procedures utilizing GC and HPLC have been developed to determine not only chemical and radiochemical purity of the final product, but also to examine the reactants used and the products formed during the preparation of 1.