Labelled compounds of potential biological interest VII. Synthesis of 3-deoxy-D-manno-[1-14C]octulosonic acid (D-manno-KDO) of high specific activity

Labelled compounds of potential biological interest VII. Synthesis of 3-deoxy-D-manno-[1-14C]octulosonic acid (D-manno-KDO) of high specific activity

The preparation of the title compound from 2‐deoxy‐D‐manno‐heptose with potassium [14C] cyanide followed by subsequent oxidation is reported. Frequent use of HPLC has made it possible to follow and optimize the different reaction steps. The synthesis was carried out on the millimole level and the pr...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1982-02, Vol.19 (2), p.239-246
Hauptverfasser: Bondesson, Göran, Fagervall, Ingrid, Gosztonyi, Tamas, Jansson, Anita, Ohlberger, Annesophie, Ab, Astra Läkemedel
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Sprache:eng
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14C
D-monno-KDD
HPLC
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container_end_page 246
container_issue 2
container_start_page 239
container_title Journal of labelled compounds & radiopharmaceuticals
container_volume 19
creator Bondesson, Göran
Fagervall, Ingrid
Gosztonyi, Tamas
Jansson, Anita
Ohlberger, Annesophie
Ab, Astra Läkemedel
description The preparation of the title compound from 2‐deoxy‐D‐manno‐heptose with potassium [14C] cyanide followed by subsequent oxidation is reported. Frequent use of HPLC has made it possible to follow and optimize the different reaction steps. The synthesis was carried out on the millimole level and the product had a specific activity of 50 mCi/mmol.
doi_str_mv 10.1002/jlcr.2580190209
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source Wiley Online Library Journals Frontfile Complete
subjects 14C
D-monno-KDD
HPLC
title Labelled compounds of potential biological interest VII. Synthesis of 3-deoxy-D-manno-[1-14C]octulosonic acid (D-manno-KDO) of high specific activity
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