Labelled compounds of potential biological interest VII. Synthesis of 3-deoxy-D-manno-[1-14C]octulosonic acid (D-manno-KDO) of high specific activity

Labelled compounds of potential biological interest VII. Synthesis of 3-deoxy-D-manno-[1-14C]octulosonic acid (D-manno-KDO) of high specific activity

The preparation of the title compound from 2‐deoxy‐D‐manno‐heptose with potassium [14C] cyanide followed by subsequent oxidation is reported. Frequent use of HPLC has made it possible to follow and optimize the different reaction steps. The synthesis was carried out on the millimole level and the pr...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1982-02, Vol.19 (2), p.239-246
Hauptverfasser: Bondesson, Göran, Fagervall, Ingrid, Gosztonyi, Tamas, Jansson, Anita, Ohlberger, Annesophie, Ab, Astra Läkemedel
Format: Artikel
Sprache:eng
Schlagworte:
14C
D-monno-KDD
HPLC
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Zusammenfassung:The preparation of the title compound from 2‐deoxy‐D‐manno‐heptose with potassium [14C] cyanide followed by subsequent oxidation is reported. Frequent use of HPLC has made it possible to follow and optimize the different reaction steps. The synthesis was carried out on the millimole level and the product had a specific activity of 50 mCi/mmol.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580190209