Preparation of a radiobrominated fluorescein for liver scanning

Preparation of a radiobrominated fluorescein for liver scanning

A radiobrominated compound, 4,5,6,7‐tetrachloro‐2′,4′,5′,7′‐tetrabromofluorescein‐77Br4 was prepared from resorcinol, tetrachlorophthallic anhydride and Na77Br by a two‐step synthesis. The precursor was identified by spectrometry. Final purification utilized column chromatography. The product was id...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1980-01, Vol.17 (1), p.73-80
Hauptverfasser: Gobuty, Allan H., Spicer, Jay A., Dressler, Robert L.
Format: Artikel
Sprache:eng
Schlagworte:
bromination
Bromine-77
radiobrominated eosin
radiobrominated Phloxine-B
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Zusammenfassung:A radiobrominated compound, 4,5,6,7‐tetrachloro‐2′,4′,5′,7′‐tetrabromofluorescein‐77Br4 was prepared from resorcinol, tetrachlorophthallic anhydride and Na77Br by a two‐step synthesis. The precursor was identified by spectrometry. Final purification utilized column chromatography. The product was identified by thin layer chromatography and spectrometry. The yield was 60% of theoretical.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580170108