Labelled compounds of potential biological interest VI. Preparation of some labelled local anaesthetic aminoethers

Labelled compounds of potential biological interest VI. Preparation of some labelled local anaesthetic aminoethers

2′‐(2‐Diisopropylaminoethoxy)‐butyrophenone (ketocaine) and 1‐butoxy‐2‐(2‐diisopropylaminoethoxy)‐benzene show a good anaesthetic effect on topical application. The synthesis of both of these compounds specifically labelled with 14C is described. The preparation of ketocaine generally labelled with...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1978, Vol.14 (5), p.639-652
Hauptverfasser: Gosztonyi, Tamas, Domeij, Karl Erik, Sandberg, Rune
Format: Artikel
Sprache:eng
Schlagworte:
Carbon-14
Deuterium
Exchange labelling
Ketocaine
Percutaneous anaesthetics
Tritium
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Zusammenfassung:2′‐(2‐Diisopropylaminoethoxy)‐butyrophenone (ketocaine) and 1‐butoxy‐2‐(2‐diisopropylaminoethoxy)‐benzene show a good anaesthetic effect on topical application. The synthesis of both of these compounds specifically labelled with 14C is described. The preparation of ketocaine generally labelled with tritium and specifically labelled with deuterium is also reported.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580140502