From ICI to AstraZeneca: the development of synthetic isotope chemistry at Alderley Park, UK

Synthetic isotope chemistry has played a key role in the discovery and development of candidate drugs for over 40 years at Alderley Park, UK. This review highlights the range of isotopically labelled compounds that have been synthesized and the applications for which they were used. The continually increasing demand for isotopically labelled compounds demonstrates their valuable contribution to the pharmaceutical industry. Copyright © 2007 John Wiley & Sons, Ltd. Synthetic isotope chemistry has played a key role in the discovery and development of candidate drugs for over 40 years at Alderley Park, UK. This review highlights the range of isotopically labelled compounds that have been synthesized, starting with 14C labelled propranolol in 1964, and the applications for which they were used. The continually increasing demand for isotopically labelled compounds demonstrates their valuable contribution to the pharmaceutical industry. Copyright © 2007 John Wiley & Sons, Ltd.