Synthesis and Biological Activity of a Potent Renin Inhibitor of the Azapeptide Type

Synthesis and Biological Activity of a Potent Renin Inhibitor of the Azapeptide Type

A highly potent renin inhibitor of the azapeptide type (2) is synthesized by starting from the hydrazine derivative 3. This peptide analogue inhibits renin in the same range (nanomolar) as its purely peptidic original 2a, but reveals much higher specificity for renin than 2a does.

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Veröffentlicht in:Liebigs Annalen der Chemie 1994-11, Vol.1994 (12), p.1231-1233
Hauptverfasser: Gante, Joachim, Krug, Michael, Lauterbach, Günter, Weitzel, Reinhard
Format: Artikel
Sprache:eng
Schlagworte:
Azapeptides
Renin inhibitor
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Beschreibung
Zusammenfassung:A highly potent renin inhibitor of the azapeptide type (2) is synthesized by starting from the hydrazine derivative 3. This peptide analogue inhibits renin in the same range (nanomolar) as its purely peptidic original 2a, but reveals much higher specificity for renin than 2a does.
ISSN:0170-2041
1099-0690
DOI:10.1002/jlac.199419941214