A Facile Solvent‐Free Synthesis of Chiral Oxazolidinone Derivatives Catalyzed by MgI 2 Etherate: An Approach to Enantiopure Synthesis of Linezolid
A highly efficient and stereoselective cycloaddition of aryl isocyanates with chiral oxiranes catalyzed by MgI 2 etherate under solvent‐free conditions was developed to prepare the chiral oxazolidinone derivatives. This methodology has been applied into the practical synthesis of antibacterial drug...
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| Veröffentlicht in: | Journal of heterocyclic chemistry 2012-09, Vol.49 (5), p.1143-1146 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A highly efficient and stereoselective cycloaddition of aryl isocyanates with chiral oxiranes catalyzed by MgI
2
etherate under solvent‐free conditions was developed to prepare the chiral oxazolidinone derivatives. This methodology has been applied into the practical synthesis of antibacterial drug linezolid. |
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| ISSN: | 0022-152X 1943-5193 |
| DOI: | 10.1002/jhet.970 |