Synthesis of New PMB-Substituted Indoles Containing 1,3,4-Oxadiazole and 1,2,4-Triazole Units

Synthesis of New PMB-Substituted Indoles Containing 1,3,4-Oxadiazole and 1,2,4-Triazole Units

A series of new indolyl‐1,3,4‐oxadiazole derivatives 3, 4, 5, 6, 7 and 10, indolyl‐1,2,4‐triazole derivatives 14 and 15 was prepared, using 1‐(4‐methoxybenzyl)‐1H‐indole‐3‐carbohydrazide (2) as a key intermediate. Some of the new compounds were evaluated for their antineoplastic activity....

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Veröffentlicht in:Journal of heterocyclic chemistry 2012-07, Vol.49 (4), p.799-805
Hauptverfasser: Farghaly, Abdel-Rahman, Haider, Norbert, Lee, Duck-Hyung
Format: Artikel
Sprache:eng
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Zusammenfassung:A series of new indolyl‐1,3,4‐oxadiazole derivatives 3, 4, 5, 6, 7 and 10, indolyl‐1,2,4‐triazole derivatives 14 and 15 was prepared, using 1‐(4‐methoxybenzyl)‐1H‐indole‐3‐carbohydrazide (2) as a key intermediate. Some of the new compounds were evaluated for their antineoplastic activity.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.864