Synthesis and DNA-binding properties of 1,10-phenanthroline analogues as intercalating-crosslinkers

Synthesis and DNA-binding properties of 1,10-phenanthroline analogues as intercalating-crosslinkers

We synthesized a series of bis(bromomethyl)‐1,10‐phenanthrolines as novel anticancer lead compounds and examined their DNA‐binding properties. 5,6‐Bis(bromomethyl)‐1,10‐phenanthroline showed DNA intercalating activity and DNA crosslinking activity, furthermore it is stable in aqueous solution....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of heterocyclic chemistry 2008-11, Vol.45 (6), p.1889-1892
Hauptverfasser: Higashi, Toshinori, Inami, Keiko, Mochizuki, Masataka
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We synthesized a series of bis(bromomethyl)‐1,10‐phenanthrolines as novel anticancer lead compounds and examined their DNA‐binding properties. 5,6‐Bis(bromomethyl)‐1,10‐phenanthroline showed DNA intercalating activity and DNA crosslinking activity, furthermore it is stable in aqueous solution.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570450654