Synthesis and bio-activity of novel iminophosphoranes

The title compounds (5a‐j) were synthesized by a two step process. 4‐Chlorophenyl and bis(2‐chloroethyl) amino‐dibromophosphites (1a and 1b) were reacted with 1,8‐diaminonaphthalene (2) to form the diazaphosphinines (3a and 3b). They were further reacted with different alkyl azides (4a‐e) in THF at...

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Veröffentlicht in:Journal of heterocyclic chemistry 2008-09, Vol.45 (5), p.1337-1341
Hauptverfasser: Mohan, Ch, Babu, B. Hari, Raju, C. Naga, Reddy, C. Suresh, Reddy, V. Janardhan
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container_end_page 1341
container_issue 5
container_start_page 1337
container_title Journal of heterocyclic chemistry
container_volume 45
creator Mohan, Ch
Babu, B. Hari
Raju, C. Naga
Reddy, C. Suresh
Reddy, V. Janardhan
description The title compounds (5a‐j) were synthesized by a two step process. 4‐Chlorophenyl and bis(2‐chloroethyl) amino‐dibromophosphites (1a and 1b) were reacted with 1,8‐diaminonaphthalene (2) to form the diazaphosphinines (3a and 3b). They were further reacted with different alkyl azides (4a‐e) in THF at 50‐55 °C under N2 atmosphere to afford the corresponding iminophosphoranes (5a‐j). Their structures were established by elemental analysis, IR, 1H, 13C, 31P NMR and Mass spectral data. All of them exhibited moderate antibacterial activity.
doi_str_mv 10.1002/jhet.5570450514
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title Synthesis and bio-activity of novel iminophosphoranes
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