A facile rearrangement of pyrroloindoline derivative to pyrroloquinoline: A new analogues of duocarmycins
Free‐radical generated at C‐7 position of indole derivative bearing N‐(3′‐chloroallyl) group prompted a regioselective intramolecular cyclization to furnish pyrroloindoline derivative, through the more favorable 5‐exo‐trig cyclization mode. The pyrroloindoline compound smoothly rearranged to pyrrolo...
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| Veröffentlicht in: | Journal of heterocyclic chemistry 2008-09, Vol.45 (5), p.1333-1336 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Free‐radical generated at C‐7 position of indole derivative bearing N‐(3′‐chloroallyl) group prompted a regioselective intramolecular cyclization to furnish pyrroloindoline derivative, through the more favorable 5‐exo‐trig cyclization mode. The pyrroloindoline compound smoothly rearranged to pyrroloquinoline under mild conditions. |
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| ISSN: | 0022-152X 1943-5193 |
| DOI: | 10.1002/jhet.5570450513 |